![140912-5-key-guion-mangold-600.jpg](https://static.clubs.nfl.com/image/private/t_editorial_landscape_mobile/t_lazy/f_auto/packers/ojvrloebwuf6hw6yquuo.jpg)
1. Letroy Guion vs. Nick Mangold – Stopping the run begins right here. Guion must hold the point of attack against one of the best centers in the game.
![140912-5-key-oline-wilkerson-600.jpg](https://static.clubs.nfl.com/image/private/t_editorial_landscape_mobile/t_lazy/f_auto/packers/tjlgpiuio01ri9mf1rfq.jpg)
2. Packers offensive line vs. Muhammad Wilkerson – Everybody's going to get a chance to block Wilkerson, who'll line up from the A gap to, figuratively speaking, the Z gap. He's the Jets' defensive playmaker and Coach Rex Ryan features Wilkerson in Ryan's attack-style defense.
![140912-5-key-cobb-nelson-cbs-600.jpg](https://static.clubs.nfl.com/image/private/t_editorial_landscape_mobile/t_lazy/f_auto/packers/khp8kd8trykmihtaz4rw.jpg)
3. Randall Cobb and Jordy Nelson vs. Jets cornerbacks – The Packers must press their advantage against cornerbacks Dee Milliner and Antonio Allen.
![140912-5-key-rodgers-smith-600.jpg](https://static.clubs.nfl.com/image/private/t_editorial_landscape_mobile/t_lazy/f_auto/packers/cliyblcnl0i276ikjhs9.jpg)
4. Aaron Rodgers vs. Geno Smith – This is a no-brainer. The Packers must claim a decided victory in the quarterback matchup.
![140912-5-key-mccarthy-ryan-600.jpg](https://static.clubs.nfl.com/image/private/t_editorial_landscape_mobile/t_lazy/f_auto/packers/thmj6k2cnc7entpdcouv.jpg)
5. Mike McCarthy vs. Rex Ryan – The head coaches offer the classic confrontation of an aggressive offensive play caller vs. a blitz-happy, never-stop-attacking defensive mastermind.
ADDITIONAL COVERAGE - SEPT. 12
Packers.com's Vic Ketchman identifies the five key matchups to look for in Sunday's Packers-Jets game.
![No Title](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/packers/xibkvfmtteyr4co4reoi.jpg)
![Stopping the run begins right here. Guion must hold the point of attack against one of the best centers in the game.](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/packers/olkwwwpffdzlpkpxdssy.jpg)
Stopping the run begins right here. Guion must hold the point of attack against one of the best centers in the game.
![Everybody's going to get a chance to block Wilkerson, who'll line up from the A gap to, figuratively speaking, the Z gap. He's the Jets' defensive playmaker and Coach Rex Ryan features Wilkerson in Ryan's attack-style defense.](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/packers/onfk0titx5jgwjnixz5u.jpg)
Everybody's going to get a chance to block Wilkerson, who'll line up from the A gap to, figuratively speaking, the Z gap. He's the Jets' defensive playmaker and Coach Rex Ryan features Wilkerson in Ryan's attack-style defense.
![The Packers must press their advantage against cornerbacks Dee Milliner and Antonio Allen.](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/packers/lncncygbvmtux0cacpvz.jpg)
The Packers must press their advantage against cornerbacks Dee Milliner and Antonio Allen.
![This is a no-brainer. The Packers must claim a decided victory in the quarterback matchup.](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/packers/fmkiuqacnwzqnnpvbmwu.jpg)
This is a no-brainer. The Packers must claim a decided victory in the quarterback matchup.
![The head coaches offer the classic confrontation of an aggressive offensive play caller vs. a blitz-happy, never-stop-attacking defensive mastermind.](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/packers/ea5jqgrtkbu8lknyrwty.jpg)
The head coaches offer the classic confrontation of an aggressive offensive play caller vs. a blitz-happy, never-stop-attacking defensive mastermind.