![141212-5-key-peppers-henderson-600.jpg](https://static.clubs.nfl.com/image/private/t_editorial_landscape_mobile/t_lazy/f_auto/packers/arckcdux7ti5cnbbzovg.jpg)
1. Julius Peppers vs. Seantrel Henderson – Peppers was quiet on Monday night vs. the Falcons, and he's challenged himself and the defense to make more noise in Buffalo. Henderson is a rookie that could have his hands full against Peppers, the wily veteran.
![141212-5-key-bulaga-williams-600.jpg](https://static.clubs.nfl.com/image/private/t_editorial_landscape_mobile/t_lazy/f_auto/packers/gpbiicruxgd18mnmwhxb.jpg)
2. Bryan Bulaga vs. Mario Williams – The Packers right tackle is having a top season and he'll be facing a Cameron Wake-like challenge in Williams, who's one of the league's sacks leader with 12.
![141212-5-key-oline-williams-dareus-600.jpg](https://static.clubs.nfl.com/image/private/t_editorial_landscape_mobile/t_lazy/f_auto/packers/pktkzpwnb9kcutbbtovi.jpg)
3. Packers interior linemen vs. Kyle Williams and Marcell Dareus – Williams and Dareus are the equivalent of Ndamukong Suh and Nick Fairley. The Bills defensive tackles are premier run-stuffers but they'll also bring a combined 15 sacks to this Sunday's game. Corey Linsley, Josh Sitton and T.J. Lang have to win in the middle to avoid disruption.
![141212-5-key-bakhtiari-hughes-600.jpg](https://static.clubs.nfl.com/image/private/t_editorial_landscape_mobile/t_lazy/f_auto/packers/tkumqguwemc51dtohgty.jpg)
4. David Bakhtiari vs. Jerry Hughes – Hughes is a speed rusher with 9.5 sacks. Aaron Rodgers' blind side must be secured.
![141212-5-key-shields-watkins-600.jpg](https://static.clubs.nfl.com/image/private/t_editorial_landscape_mobile/t_lazy/f_auto/packers/umeny3g1bjkr2rtiroil.jpg)
5. Sam Shields vs. Sammy Watkins – Watkins is the Bills' big-play threat. The Packers must deny big plays and make the Bills drive the ball.
Packers.com's Vic Ketchman identifies the five key matchups to look for in Sunday's Packers-Bills game.
![No Title](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/packers/bqwfdyc65e8oe1cy6vpf.jpg)
![Peppers was quiet on Monday night vs. the Falcons, and he's challenged himself and the defense to make more noise in Buffalo. Henderson is a rookie that could have his hands full against Peppers, the wily veteran.](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/packers/mc55t2epbzetbaymcnds.jpg)
Peppers was quiet on Monday night vs. the Falcons, and he's challenged himself and the defense to make more noise in Buffalo. Henderson is a rookie that could have his hands full against Peppers, the wily veteran.
![The Packers right tackle is having a top season and he'll be facing a Cameron Wake-like challenge in Williams, who's one of the league's sacks leader with 12.](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/packers/zqbn5mjdafzzi15tfatl.jpg)
The Packers right tackle is having a top season and he'll be facing a Cameron Wake-like challenge in Williams, who's one of the league's sacks leader with 12.
![Williams and Dareus are the equivalent of Ndamukong Suh and Nick Fairley. The Bills defensive tackles are premier run-stuffers but they'll also bring a combined 15 sacks to this Sunday's game. Corey Linsley, Josh Sitton and T.J. Lang have to win in the middle to avoid disruption.](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/packers/rr5ev6njjfydicxr5v9c.jpg)
Williams and Dareus are the equivalent of Ndamukong Suh and Nick Fairley. The Bills defensive tackles are premier run-stuffers but they'll also bring a combined 15 sacks to this Sunday's game. Corey Linsley, Josh Sitton and T.J. Lang have to win in the middle to avoid disruption.
![Hughes is a speed rusher with 9.5 sacks. Aaron Rodgers' blind side must be secured.](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/packers/kqy7qyswrlxxbydxfgbs.jpg)
Hughes is a speed rusher with 9.5 sacks. Aaron Rodgers' blind side must be secured.
![Watkins is the Bills' big-play threat. The Packers must deny big plays and make the Bills drive the ball.](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/packers/kgs1caetiehhsazbseoz.jpg)
Watkins is the Bills' big-play threat. The Packers must deny big plays and make the Bills drive the ball.