Christian Uphoff played for Illinois State from 2017-19, appearing in 37 games with 26 starts that all came over his final two seasons. His team's fall season was canceled in 2020 due to COVID-19, but he played in the Reese's Senior Bowl. In 2019, Uphoff started all 15 games, ranked No. 4 on the team with 70 tackles, tied for No. 3 with two INTs and also recorded seven passes defensed, 5.5 tackles for a loss and averaged 29.5 yards on six kickoff returns with a long of 59 yards. He was an All-Missouri Valley Football Conference honorable mention selection in 2018.